Contact:

Phone:510-642-3134
Email:

Education:

B.Sc. (2002) Biology and Psychology, Hebrew University of Jerusalem.
M.A. (2005) Cognitive Psychology, Hebrew University.
Ph.D. (2010) Neuroscience, University of California, Berkeley.

Research interests:

My work focuses on the neural mechanisms of perceptual learning in the human visual system. I am using fMRI in order to measure changes occuring, with learning, in the human brain. In addition, I am conducting pharmacological experiments aimed at understanding the role of the cholinergic system in perceptual learning.

Additional experiments, in collaboration with Bill Prinzmetal and with Mark D'Esposito and Deanna Wallace are aimed at understanding the role of acetylcholine and dopamine in the allocation of voluntary and involuntary attention.

Together with others in the lab, and in collaboration with Jong Yoon at the University of California, Davis, I am also investigating visual processing in schizophrenic patients. We are using fMRI and MRS, in conjunction with behavioral psychophysical testing in order to understand basic circuit properties in the brain of these patients.

In am one of the developers of nitime, a free, open-source software package for the analysis of time-series from neuroscience experiments.



Publications:

A. Rokem, J.H. Yoon, R.E. Ooms, R.J. Maddock, M. Minzenberg and M.A. Silver (submitted). Broader visual orientation tuning in patients with schizophrenia.

A. Rokem, A. Landau, W. Prinzmetal, D. Wallace, M.A. Silver and M. D'Esposito (in press). Modulation of inhibition of return by the dopamine D2 receptor agonist bromocriptine depends on individual DAT1 genotype. Cerebral Cortex.

A. Rokem and M.A. Silver (2010) Cholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humans. Current Biology 20: 1723-1728 pdf supplementary materials

A. Rokem, A. Landau, D. Garg, W. Prinzmetal and M.A. Silver (2010) Effects of cholinergic enhancement on voluntary and involuntary visual spatial attention in healthy humans. Neuropsychopharmacology 35: 2538-44 pdf

J.H. Yoon, R.J. Maddock, A. Rokem , M.A. Silver, M.J. Minzenberg, J.D. Ragland and C.S. Carter (2010). Gamma-aminobutyric acid concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. Journal of Neuroscience 30:3777-3781. pdf

A. Rokem, M. Trumpis and F. Perez (2009). Nitime: time-series analysis for neuroimaging data. In Proceedings of the 8th Python in Science Conference (SciPy 2009) G. Varoquaux, S. van der Walt, J. Millman (Eds.) pdf

J. Yoon, A. Rokem, M.A. Silver, M.J. Minzenberg and C.S. Carter (2009). Diminished Orientation-Specific Contextual Modulation of Visual Processing in Schizophrenia. Schizophrenia Bulletin 35: 1078-84 pdf

A. Rokem and M.A. Silver (2009) A model of encoding and decoding in V1 and MT accounts accounts for motion perception anisotropies in the human visual system. Brain Research 1299: 3-16. pdf

H. Eyherabide, A. Rokem, A.V.M. Herz, I. Samengo (2009) Burst generate a non-reducible spike-pattern code. Frontiers in Neuroscience 3: 8-14. pdf

A. Rokem and M. Ahissar (2009) Interactions of cognitive and auditory abilities in congenitally blind individuals. Neuropsychologia 47:843-8 pdf

H.G. Eyherabide, A. Rokem , A.V.M. Herz and I. Samengo (2008). Burst Firing as a Neural Code in an Insect Auditory System. Frontiers in Computational Neuroscience 2:3. pdf

A. Rokem, S. Watzl, T. Gollisch, M. Stemmler, A.V.M. Herz and I. Samengo (2006). Spike-Timing Precision Underlies the Coding Efficiency of Auditory Receptor Neurons. The Journal of Neurophysiology 95: 2541-2552. pdf